The Cardinals have ripped off 10 straight wins since, capped by a stunning turnaround in the championship game of the Big East tournament. They trailed Syracuse by 16 points early in the second half, but put on the full-court pressure and won in a romp, 78-61.
The Big East, in its final year before the basketball-only schools break away to form their own league, led the way with eight teams in the NCAA field.
"We are ecstatic to be the No. 1 seed, particularly after finishing off one of the greatest conferences in the history of college basketball with a Big East championship," Louisville coach Rick Pitino said. "Our players showed incredible grit to come back from 16 points down. We know we will be challenged right away in one of the toughest brackets that I've seen in quite some time. I think our guys are up for the challenge."
No. 7 Kansas (29-5) moved up to take the second overall seed after an impressive run through the Big 12 tournament, punctuated by a 70-54 victory over rival Kansas State in the title game. No. 3 Indiana (28-6) is third overall despite falling to Wisconsin in the Big Ten semifinals. The Zags claimed the last of the coveted No. 1 seeds, edging out Atlantic Coast Conference champion Miami.
The top spots are significant in at least one respect: A No. 1 has never lost to a 16th-seeded team.
"It's going to happen. A 16 is going to beat a 1 eventually," Kansas coach Bill Self said. "This is a unique tournament. I haven't studied the bracket, but I would expect the unexpected. There will be a lot of mild upsets in this tournament."
Miami, known more as a football school, became the first ACC team to be denied a top seed after winning both the regular season and the conference tournament.